Pakse is the main transportation hub for the far south of Laos, so it's relatively easy to get there or away to other places. Note the emphasis on 'relatively'. This part of Laos is still not a huge tourist draw, so while there are ways to get there, they aren't overly plentiful.
Getting to Pakse by air: Pakse has a small airport, served by the national carrier, Lao Airlines. You can reach Pakse from the other main domestic centers of Vientiane and Luang Prabang. Internationals connections include Siem Reap, Phnom Penh and Bangkok. Flights to Cambodian destinations are daily, while at last check Bangkok connections were only twice a week.
Getting to Pakse by bus: Bus is an easy option for getting to or from Pakse from other nearby destinations, such as Champasak and the 4,000 Islands. You can also get long distance buses to any other part of Laos from Pakse. Given the scarcity of flights between Bangkok and Pakse, the border crossing from Ubon Ratchathani in Northeastern Thailand to Pakse is one of the most popular ways to reach here. See our article on the Ubon to Pakse border crossing for full details.
You can also reach Pakse by boat from the Champasak or 4,000 Islands areas downriver, although it is much slower than by bus.